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Microscopy Facilities
at the University of California, Berkeley

There are three core laboratories on campus that offer expertise, instruction, and instrumentation in optical microscopy for research.

The Biological Imaging Facility is a core microscope imaging lab at the University of California, Berkeley.
The BIF specializes in Widefield, Confocal, Deconvolution, Spinning Disk, and Super-Resolution fluorescence microscopy (SIM, PALM, TIRF).

Past IOMs
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Immunolocalization of incretin hormone receptors and substance P on cell bodies and sensory nerves of the mucosal lymphatic lacteals of the mouse intestinal cells.  Incretins are peptide hormones that are secreted from the small intestinal mucosa, in response to a meal, that greatly enhance insulin's mode of action. Substance P (SP) is a neuropeptide found in the brain, spinal cord, and is associated with inflammatory processes and pain. This micrograph shows the immunolocalization of incretin receptors (red) and, SP (green), on cells and neuro fibers within the lumen of cells that carry lymphatic fluid derived from the intestine.  Cells that contain both the incretin receptor and substance P (SP) appear as yellow. This suggests that incretins can act to enhance insulin function as well as modulate inflammatory responses in the intestine. This 3D image was captured using the Zeiss Elyra PS.1 super-resolution microscope, and presented using Bitplane Imaris Colocalization and Isosurface rendering, all in the BIF.

Image contributed by Rebecca Hsiao, Gerald Yeung and Cherry Liu of Aponte Lab

Sat, May 7, 2016